Abstract P098

Omitting radiation in young adult females with Hodgkin’s disease, Is there an impact on outcome?

Background: Ionizing radiation is a breast cancer risk factor. This retrospective study aims to compare the outcome of young adolescent females diagnosed and treated with classic Hodgkin lymphoma, who received chemotherapy while omitting radiotherapy, for fear of the increased risk of breast cancer, and those who received chemotherapy followed by radiotherapy. In an attempt to explore the impact of radiotherapy on the outcome, and to record the late side effects of radiotherapy as well as the incidence of breast cancer among these patients. About 166 young adolescent females between 12 and 18 years old were diagnosed and treated with classic Hodgkin lymphoma in the Children’s Cancer Hospital Egypt from July 2007 till the end of 2018, the no radiotherapy (RT) group (72 patients) received chemotherapy while omitting radiotherapy, the RT group (94 patients) received chemotherapy and radiotherapy, with 5years OS 93%, 87% respectively, and with 5years EFS 74%, 85% respectively, with P-value 0.062. The initial stage and response to treatment using interim PET CT scan post-second cycle chemotherapy were documented. The outcomes were nearly identical in the no RT or RT groups. In conclusion, omitting radiation therapy did not affect the 5-year EFS; nevertheless, the existence of positive B symptoms, an advanced stage initially, or a poor response to treatment, all had an impact on the 5-year EFS.

Keywords: Hodgkin lymphoma, chemotherapy, radiotherapy, breast cancer, advanced stage, B symptoms, interim PET CT.

Authors

Asmaa Hamoda, samah semary, eman naguib, Madeeha A.T. El Wakeel, mohamed zaghloul, salma abdelaziz, mahmoud hamza, Emad Moussa