Background: Despite the high cure rate of childhood Hodgkin lymphoma (HL) patients with refractory HL remain incurable with standard therapies. Autologous or allogeneic heamotopoietic stem cell transplantation (HSCT) is considered the most effective method of consolidation in relapsed or refractory HL treatment. Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate that has become the preferred therapy option for adults with HL who have relapsed after or are ineligible for auto HSCT, but data relating to pediatric patients are very limited. Objectives: We aimed to report a case of effective and tolerable BV-containing treatment in an adolescent with refractory HL. Case report: A 17-year-old female with enlarged cervical, supra-/subclavicular, axillary, mediastinum lymph nodes and multiple lesions in both lungs was admitted to our hospital. FDG-PET/CT and lymph node biopsy were performed and nodular sclerosis HL stage IVA was diagnosed. Treatment was administered according to modified DAL-HD-95 protocol, and consisted of 6 courses of chemotherapy (2OPPA/4COPP) plus radiation therapy of the involved fields (20 Gy). Partial response was achieved after the 2nd cycle OPPA and stable disease was observing during the all remaining treatment. One month after the end of treatment the patient showed disease progression in mediastinum and lungs, confirmed by FDG-PET/CT and lung biopsy. Positive response was obtained after the two courses (IEP, ABVD) of second-line therapy, but patient remained PET-positive. Treatment was continued with 3 cycles VV (BV 1.8 mg/kg/bendamustine/dexamethasone), PET-negative complete remission was achieved and autoHSCT (conditioning regimen consisted of BEAM) with allogeneic bone marrow-derived mesenchymal stem cells cotransplantation was subsequently performed. Further the patient received adjuvant monotherapy with BV 1.2 mg/kg every 3 weeks (a total of 12 doses). The only evident side effect seen in BV treatment was deteriorating peripheral neuropathy. Patient remains in PET-negative complete remission for 14 months after autoHSCT and 4 months after the last dose of BV. Conclusion: Our experience should encourage to use BV in combination with chemotherapy or even alone in pediatric patients with refractory HL.