We studied the prognostic significance of the absolute neutrophil/lymphocyte ratio (ANC/ALC), the absolute lymphocyte/monocyte ratio (ALC/AMC), absolute eosinophil count (AEoC) and their contribution to prognostic value of the International Prognostic Score (IPS) in 361 advanced Hodgkin lymphoma (HL) patients. The receiver operating characteristic curve identified the best cut-off values as 4.3 for ANC/ALC and 2.0 for ALC/AMC. Univariate analysis showed that all analyzed factors were associated with lower OS: ANC/ALC>4.3 (OS5yrs with/without risk factor 72% vs. 85%, respectively, p<0.01); ALC/AMC<2 (OS5yrs with/without risk factor 64% vs. 86%, respectively, p<0.01); AEoC<0.5x10e6/L (OS5yrs with/without risk factor 76% vs. 88%, respectively, p<0.01); IPS >2 (OS5yrs with/without risk factor 66% vs. 86%, respectively, p<0.01). Apart from AEoC, these factors also had a significant impact on EFS - ANC/ALC>4.3 (EFS5yrs with/without risk factor 55% vs. 72%, respectively, p<0.01); ALC/AMC <2 (EFS5yrs with/without risk factor 46% vs. 73%, respectively, p<0.01); IPS >2 (EFS5yrs with/without risk factor 51% vs. 71%, respectively, p<0.01). Overall survival multivariate analysis identified ALC/AMC<2, IPS>2 and AEoC<0.5x10e6/L as prognostic factors for poor OS (p<0.01; p<0.01; p<0.01 respectively). In a respective model for EFS, ALC/AMC<2 and IPS>2 were also significant (p<0.01; p<0.05, respectively). After evaluating ALC/AMC and IPS, we stratified patients into 3 progressively-worse-outcome groups (low-risk: 0; intermediate: 1 risk factor; high: 2 risk factors) both for OS (91%; 74%; 56%, p<0.01) and EFS (77%; 58%; 41%, p<0.01). Furthermore, we observed that patients with eosinophilia, AEoC>0.5x10e6/L had significantly better OS in group with ALC/AMC<2 (82% vs. 58%, p<0.01), as well as in low IPS group (97% vs. 84%, p<0.05), but not in group with high IPS (75% vs. 64%, p>0.05). Our study encourages the combination of ALC/AMC with IPS, thus providing an improved risk prediction in advanced HL patients. Moreover, present peripheral blood eosinophilia separates patients with better prognosis in poor prognostic group.