Background: Brentuximab Vedotin (BV) is currently used for the treatment of relapsed/refractory Hodgkin Lymphoma (HL). Accordingly to preliminary data, BV might be useful also against Mycosis Fungoides (MF), even in patients with weak CD30 expression. Here we describe a case of relapsed HL and concomitant MF treated with BV. Clinical Report: A 73-year-old man was referred to our Center in September 2015 for relapsed HL and simultaneous MF. Medical history included hypertension, moderate chronic renal impairment and acute heart failure secondary to atrioventricular block. MF was diagnosed in 1987 and UVA, UVB and PUVA were delivered, with short term partial remissions. Classical HL, clinical stage IIIB, was diagnosed in 2004 and patient obtained complete remission (CR) after 6 ABVD cycles. After 7 years (68 years-old), HL relapse was histologically documented and clinical stage was IIIA. Three cycles of IGEV chemotherapy obtained a second CR and 30 Gy involved-field radiotherapy was given as consolidation. A third HL relapse, biopsy proven with strong CD30 expression, occurred 3 years later and clinical stage was IIIA. At time of HL relapse MF was in stage III and patient presented scaly erythematous plaques distributed over most of his body. Patient started BV therapy at the reduced dose of 1.2 mg/kg/3ws due to creatinine-clearance of 53 ml/min. A significant regression of the skin lesions was observed after the first BV dose, and after 4 BV cycles both MF and HL achieved a CR, documented by clinical examination and PET scan, respectively. Twelve of the 16 BV planned doses have been administered, with no significant toxicity and no recurrence of both HL and MF. Conclusion: This case confirms that BV is a well tolerated and effective treatment for HL; the quick response of the concomitant MF that we observed encourages further investigations on the role of BV also in this setting.