In advanced Hodgkin lymphoma, allogeneic hematopoietic stem cell transplantation can represents a potential curative option. In this study, we analyzed the outcome of advanced HL patients who received haplo-HSCT using the unmanipulated stem cell and PT-Cy. 62 consecutive HL patients undergoing T-cell replete haploidentical transplantation with PT-Cy. ANC and platelets engraftment was observed in 94% and 82% of patients. The 100-day cumulative incidence (CI) of grade 2-4 and 3-4 aGVHD was 23% and 4%, respectively and the CI of cGVHD (overall) was 16. The median follow-up was 32 months. The 3-year OS, PFS, relapse rate was 63%, 59%, and 21%, respectively. The 1-year NRM was 20%. In multivariate analysis, factors negatively associated with OS were uncontrolled disease status and higher than 2 HCT-CI. PBSC was an independent protective factor. The same factors were predictive for PFS, except for HCT-CI 1. Disease status other than CR was predictive of relapse. Haplo-HSCT with PT-Cy looks particularly effective against HL cells, and it seem to work better than other donors. However, prospective studies are needed to confirm the these results.