Abstract P011

Data Collaborations Accelerate Pediatric Hodgkin Lymphoma Research Through NODAL

Background: Advances in pediatric oncology are in large part attributed to collaboration among international research cooperative groups. Seeking to advance collaboration and standardize aspects of diagnosis, staging, treatment, and response assessment, pediatric Hodgkin lymphoma (HL) researchers established the Hodgkin Lymphoma Data Collaboration (NODAL) consortium and partnered with the Pediatric Cancer Data Commons (PCDC) (10), led by Data for the Common Good (D4CG), to develop consensus data standards and realize a data commons for pediatric HL. Methods: With a goal to accelerate research for pediatric HL, NODAL was founded in 2018 through the execution of a Memorandum of Understanding between the Children’s Oncology Group (COG) and the Pediatric Hodgkin Consortium (PHC). Since that time, many milestones have been achieved including a) an executive committee and a comprehensive governance structure were established, b) NODAL members worked to formulate a harmonized data dictionary from previous clinical trials, c) data contributor agreements were signed by each group, d) data were harmonized according to the data dictionary, and e) the COG and PHC transferred data for collaborative research questions. Results: As of May 2024, the HL data dictionary incudes 203 standardized elements that were used to harmonize clinical trials data on 2,437 participants from six clinical trials conducted by Children’s Oncology Group trials (AHOD0031, AHOD03P1) and Pediatric Hodgkin Consortium trials (HLHR13, HOD05, HOD08, HOD99). By Ann Arbor staging, the participants break down: Stage I–169, Stage II–1,274, Stage III-425, Stage IV-386 (see Table 1). Elements in the data dictionary include demographics, initial disease characteristics, therapy, response assessment, toxicity and survival status. Aggregate data can be freely explored using the publicly accessible PCDC data portal (https://portal.pedscommons.org/login). Conclusion: NODAL facilitates research and overcomes barriers to cross trial comparisons through data access via the Pediatric Cancer Data Commons. We are engaging with pediatric HL researchers around the world and invite contribution of clinical trial and registry datasets to all interested groups with complete maintenance of governance by each contributor. We also invite researchers to propose projects that use the growing Hodgkin lymphoma dataset by completing a brief project request form review by the NODAL Executive Committee.

Authors

Flerlage Jamie, Suzi Birz, Sharon M. Castellino, Tara O. Henderson, John Lucas, Lindsay A. Renfro, Yiwang Zhou, Samuel Volchenboum, Brian Furner, Michael Watkins, Kara M. Kelly